Black Lagoon 6 features story and art by Rei Hiroe.

After their trip to Japan, the crew unwinds back in Roanapur. The R&R doesn't last long - Jane, a counterfeiter on the run from Florida-based gangsters, seeks refuge with Sister P.W. Deegan's Church of Violence, kicking off a hot pursuit involving some of Roanapur's more colorful guns-for-hire.

Later, half a world away in Venezuela, a bomb blast shatters what calm Garcia and Roberta have managed to restore to their lives. Garcia tries to sway Roberta from seeking payback, but the "Bloodhound of Florencia" will have her vengeance, and woe to anyone who gets in her way!