Ryo Saeba is known as City Hunter, the top “sweeper” within the underworld. Based in Shinjuku as a private detective, he and his partner Kaoru Makimura take on a variety of clients. Their latest case is provided by Angie, a filmmaker, with a simple request – to find her missing cat. Ryo is thrilled by Angie's beautiful looks while Kaori is thrilled by the hefty reward… Meanwhile, Saeko Nogami of the Metropolitan Police investigates an invention of the biotech company Zoltech – a dark technology that turns soldiers on the battlefield into superhumans. Created at the request of a mysterious underworld organization, this invention is the newest version of Angel Dust, which once almost destroyed Ryo and sent his partner Hideyuki makimura to his death.

Can these two cases possibly be linked? There's clearly more to Angie's request than she's willing to share, and the truth around Angel Dust is about to launch Ryo into a fateful showdown with links to Ryo's very origin as a sweeper…