Fushigi Yugi BIG Edition volume 2 collects volumes 4-6 in an omnibus format and features story and art by Yuu Watase.

An embittered Yui has sworn revenge on Miaka, believing that her best friend had no intention of rescuing her from the Qu-Dong empire. Now Yui has become the Priestess of Seiryu, the enemy of the Hong-Nan empire, and a rival for Tamahome's affections!

Tamahome leaves Miaka to travel to Qu-Dong in an attempt to stop a war between the two territories from breaking out, and Hotohori starts to woo Miaka in his absence. Laden with Hotohori's gold and a big appetite, Miaka embarks on a journey to find the remaining three Celestial Warriors, who will help her in her quest to save the Hong-Nan empire and return home. But her search leads her into a lair of bandits and to a plague-cursed town where she has to die to survive!