In the twilight of his career, master thief Lupin the Third's latest and greatest caper has hit a snag. What should've been bags of cash from a national casino turns out to be expert counterfeits! Together with his partner-in-crime Jigen, Lupin heads to the remote European nation of Cagliostro to exact revenge.

Not everything goes as planned; the two encounter Clarisse, a royal damsel in distress being forced to marry the sinister Count Cagliostro against her will. Saving her won't be easy, however, as Lupin and Jigen - together with Lupin's unpredictable ex-girlfriend Fujiko and the swordsman Goemon - must fight their way through a trap-filled castle, a deadly dungeon, and an army of professional assassins! Can Lupin rescue the girl, evade the cuffs of his long-time nemesis Inspector Zenigata, and uncover the secret treasures of The Castle of Cagliostro?