Sakura, Saku manga volume 1 features story and art by Io Sakisaka.

A mysterious boy comes to Saku Fujigaya’s rescue when she falls ill on a train, but he leaves before she can thank him. After this experience, Saku never ignores strangers in need of help to emulate the boy who helped her.

Saku Fujigaya would like to thank the boy who helped her, but all she has is a note signed "Ryosuke Sakura." She discovers that a boy at her high school, Haruki Sakura, has an older brother named Ryosuke. She asks Haruki to deliver her thank-you letter to Ryosuke, but why does he refuse?